RETINOATE PROGRAM

Aqua (Water), Glycerin, PPG-13-decyltetradeceth-24, Dimethicone, Trisiloxane, Butylene Glycol, Niacinamide, Caprylic/Capric Triglyceride, Isopropyl Lauroyl Sarcosinate, Phenoxyethanol, Ceteth-10, Laureth-4, Retinyl Retinoate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Triethanolamine, Ethylhexylglycerin, Disodium EDTA, 1,2-Hexanediol, Mica, CI 77891 (Titanium dioxide), Benzotriazolyl Dodecyl p-cresol, Sodium Metabisulfite, Caprylhydroxamic Acid, DiethylhexylSyringylidenemalonate, CI 14700 (Red 4), Tocopherol.

*Our formulas may be evolved, please always refer to the list of ingredients on the packaging.

Latest innovation from our laboratory, Chrono Repair is the ultimate program for treating the signs of aging. Each treatment in the range has been designed to act in synergy and provide a complete response to the effects of the passage of time.

Retinyl retinoate is a synthetic molecule created by attaching retinol to retinoic acid.

This unique structure offers several advantages:
Increased stability: The attachment makes the molecule more stable than pure retinol, which is notoriously difficult to formulate due to its instability.
Enhanced activity: It is more active than retinol while maintaining a gentler profile than pure retinoic acid.

Mechanism of Action
When applied to the skin, retinyl retinoate undergoes a unique conversion process:
It breaks down into both retinoic acid and retinol.
The retinoic acid component becomes immediately active.
The retinol component undergoes further conversion to retinoic acid, providing both immediate and delayed benefits.
This dual-action mechanism sets it apart from other retinoids, potentially offering more comprehensive and sustained effects.

Benefits and Efficacy
Research has shown that retinyl retinoate offers several advantages in skincare:
Anti-aging effects: Studies indicate it is significantly more effective than placebo and retinol in improving skin wrinkles.
Collagen synthesis: It shows higher biological activity than retinol in promoting collagen production.
Hyaluronic acid production: Retinyl retinoate increases hyaluronic acid production more than other retinoids.
Acne treatment: Clinical studies have demonstrated its efficacy in reducing both inflammatory and non-inflammatory acne lesions.
Reduced irritation: It appears to be less irritating than other retinoids while maintaining high efficacy1.
Comparison to Other Retinoids
In the hierarchy of retinoids, retinyl retinoate occupies a unique position:
It is more potent than retinol, with some sources claiming it to be 8 times more powerful.
Its effects are described as being between those of retinol and retinoic acid.
It offers a better balance of efficacy and tolerability compared to stronger retinoids like tazarotene or tretinoin.

Conclusion
Retinyl retinoate represents an exciting advancement in retinoid technology. Its unique properties make it a promising ingredient for those seeking effective anti-aging and acne-fighting benefits with potentially reduced irritation compared to traditional retinoids. As more research emerges, it may become an increasingly popular choice in both over-the-counter and professional skincare products.

The skin is visibly younger, firmed, smoothed, hydrated and plumped.

Sources:

• Kim, H., et al. “Improvement in skin wrinkles from the use of photostable retinyl retinoate: a randomized controlled trial.” British Journal of Dermatology 162.3 (2010): 497-502.
• Kim, Hyojung, et al. “Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative.” Bioorganic & medicinal chemistry 16.12 (2008): 6387-6393.
• Kim, Jin Eun, et al. “Retinyl retinoate induces hyaluronan production and less irritation than other retinoids.” The Journal of dermatology 37.5 (2010): 448-454.