BIPHASIC MAKEUP REMOVER

INGREDIENTS: Aqua (Water), Coco-Caprylate/Caprate (Emollient), Caprylic/Capric Triglyceride (Skin Conditioning), Glycerin*** (Humectant), Bisabolol* (Soothing), Levulinic Acid (Skin Conditioning), Arginine (Skin Conditioning), Sodium Levulinate (Skin Conditioning), Brassica Campestris (Rapeseed) Seed Oil* (Skin Conditioning), Sodium Benzoate (Preservative), Aloe Barbadensis (Aloe Vera) Leaf Juice Powder* (Skin Conditioning), Caprylyl/Capryl Glucoside (Foaming), Hexapeptide-11 (Skin Conditioning), Polygonum Tinctorium Leaf Extract* (Skin Conditioning), Leuconostoc/Radish Root Ferment Filtrate (Antimicrobial), Rosmarinus Officinalis (Rosemary) Leaf Extract* (Skin Conditioning).

COSMOS ORGANIC certified by Ecocert Greenlife according to COSMOS standard.

*Organic. ***Made using organic and non-organic ingredients.

25% Organic. 99% natural origin.

• Dyers’ knotweed (extracted from the leaves of Persicaria tinctoria – molecule of interest indirubine)

We know that sensitive skin is characterized by an alteration of the skin barrier, resulting in transepidermal water loss (TEWL) that can promote transcutaneous penetration of irritants such as pollutants and UV, triggering inflammatory disorders.

This is why our phytocompound is able to both reduce the pro-inflammatory response of keratinocytes and protect the skin barrier of the skin. Indirubine offers this perfect combination. Its activity on the skin is well documented. 10

It acts:
– On the physical barrier of the skin to reduce inflammatory lesions 1, 2, 3, 4, restore an optimal balance between keratinocyte proliferation and keratinocyte differentiation 1, 2, 3, and repair junctions that play a crucial role in the integrity of the skin barrier 5
– On the immune barrier by modulating inflammation (release of cytokines, NO, IgE, …) 6, 7, 8, 9

• Peptide solution (grown in an environment rich in amino acids; after fermentation, the hexapeptide is isolated using various filtration techniques):

“Hexapeptide 11 has several anti-aging benefits such as increasing skin tone and elasticity and can also improve skin hydration.” 11

• Alpha-bisabolol (extraction of candeia bark oil)
Since the 1990s, natural alpha-bisabolol has been obtained from the bark of “Candeia” containing an oil with a high alpha-bisabolol content that can be extracted by steam distillation.

This sesquiterpene is well known for its anti-inflammatory, antibacterial and antifungal properties. In vivo tests show that alpha-bisabolol is an effective topical anti-inflammatory agent in experimental models of acute dermatitis and suggest that it could serve as a source for the development of effective drugs in inflammatory skin disorders such as atopic or contact dermatitis and psoriasis. Another study showed that alpha bisabolol reduced the expression of cyclooxygenase-2 (COX-2), an enzyme that catalyzes the synthesis of inflammatory agents. Alpha-bisabolol exerts anti-inflammatory effects by downregulating the expression of the COX-2 gene. 12 , 13 , 14

SOURCES:

1

Yin-Ku Lin and al., Anti-psoriatic effects of indigo naturalis on the proliferation and differentiation of keratinocytes with indirubin as the active component. Journal of Dermatological Science 54 (2009) 168–174.

2

Mi Hye Kim and al., Indirubin, a purple 3,2- bisindole, inhibited allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model. Journal of Ethnopharmacology 145 (2013) 214–219.

3

Ken Miyoshi and al., Attenuation of psoriasis-like skin lesion in a mouse model by topical treatment with indirubin and its derivative E804. Journal of Dermatological Science 65 (2012) 68–76.

4

Y.-K. Lin and al., Comparison of indirubin concentrations in indigo naturalis ointment for psoriasis treatment: a randomized, double blind,dosage-controlled trial. British Journal of Dermatology (2018) 178, pp124–131.

5

Yin-Ku Lin and al., Indigo naturalis upregulates claudin-1 expression in human keratinocytes and psoriatic lesions. Journal of Ethnopharmacology 145 (2013) 614–620.

6

Jinyoung Lee and al., Anti-inflammatory activity of Persicaria tinctowria extract against the environmental toxic stress-induced inflammation in HaCaT keratinocytes. Natural Products Science College of Pharmacy The Graduate School Seoul National University (2016).

7

Tatsuya Ishihara and al., Polygonum tinctorium extract suppresses nitric oxide production by activated macrophages through inhibiting inducible nitric oxide synthase expression. Journal of Ethnopharmacology 72 (2000) 141–150.

8

Mi Hye Kim and al., Indirubin, a purple 3,2- bisindole, inhibited allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model. Journal of Ethnopharmacology 145 (2013) 214–219.

9

Toshio Kunikata and al., Indirubin inhibits inflammatory reactions in delayed-type hypersensitivity. European Journal of Pharmacology 410 (2000) 93–100.

10

Hallstar [online].

11

Formulator Sample Shop [online].

12

The antimicrobial activity of alpha-bisabolol and tea tree oil against Solobacterium moorei, a Grampositive bacterium associated with halitosis – Marcel Forrer, Eva M. Kulik, Andreas Filippi, Tuomas Waltimo

13

α-Bisabolol attenuates visceral nociception and inflammation in mice – Gerlânia de O. Leite, Laura H.I. Leite, Renata de S. Sampaio, Mariana Késsia A. Araruna, Irwin Rose A. de Menezes, José Galberto M. da Costa, Adriana R. Campos

14

Inhibitory effects of (-)-α-bisabolol on LPS-induced inflammatory response in RAW264.7 macrophages – Kim S, Jung E, Kim JH, Park YH, Lee J, Park D